Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Hexylcaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 1.00 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexylcaine SCHEMBL34238 | 1.00 | LMNA (1.00) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL34239 | 1.00 | LMNA (1.00) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL24192 | 0.99 | LMNA (0.97) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL24194 | 0.99 | LMNA (0.97) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL3076544 | 0.97 | LMNA (0.95) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL14955131 | 0.80 | LMNA (0.66) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL28803763 | 0.79 | LMNA (0.65) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Benzoic Acid SCHEMBL3676802 | 0.79 | LMNA (0.65) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL28544688 | 0.78 | LMNA (0.64) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL18747647 | 0.78 | LMNA (0.64) | LMNACYP1A2CYP2D6SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2490635-A1 | CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN | Nexisvision, Inc. (US) | 2012-08-29 | — | — | EP | claimed |
| WO-2011050327-A1 | CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN | FORSIGHT LABS LLC (US) | 2011-04-28 | — | — | WO | claimed |
| CN-1072965-C | Improved topical delivery of drugs | PROCTER & GAMBLE (US) | 2001-10-17 | — | — | CN | claimed |
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| CN-1091317-A | Improve the part input of medicine | PROCTER & GAMBLE (US) | 1994-08-31 | — | — | CN | claimed |
| CN-1079896-A | The compositions of topical aromatic releasing | RICHARDSON VICKS INC (US) | 1993-12-29 | — | — | CN | claimed |
| CN-1072863-A | Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery | RICHARDSON VICKS INC (US) | 1993-06-09 | — | — | CN | claimed |
| US-10722562-B2 | Combinatorial analysis and repair | IMMUDEX APS (DK) | 2020-07-28 | — | — | US | disclosed |
| EP-3260092-A1 | CORNEAL DENERVATION FOR TREATMENT OF OCULAR PAIN | Nexisvision, Inc. (US) | 2017-12-27 | — | — | EP | disclosed |
| US-20110212090-A1 | Combinatorial Analysis and Repair | DAKO DENMARK A/S | 2011-09-01 | — | — | US | disclosed |
| WO-2010009735-A2 | COMBINATORIAL ANALYSIS AND REPAIR | DAKO DENMARK A/S (DK) | 2010-01-28 | — | — | WO | disclosed |
| CN-101057824-A | Injectable multimodal polymer depot compositions and uses thereof | ALZA CORP (US) | 2007-10-24 | — | — | CN | disclosed |
| CN-1822816-A | Implantable elastomeric depot compositions and uses thereof | ALZA CORP (US) | 2006-08-23 | — | — | CN | disclosed |
| CN-1079896-A | The compositions of topical aromatic releasing | RICHARDSON VICKS INC (US) | 1993-12-29 | — | — | CN | disclosed |
| CN-1048979-A | Film forming preparation of original position and method on tissue | ZILA PHARM INC (US) | 1991-02-06 | — | — | CN | disclosed |
| EP-0401903-A2 | The use of vanilloids for the treatment of respiratory diseases or disorders | THE PROCTER & GAMBLE COMPANY (US) | 1990-12-12 | — | — | EP | disclosed |
| US-4423725-A | Multiple surgical cuff | BARAN OSTAP E | 1984-01-03 | — | — | US | disclosed |
| US-4417576-A | Double-wall surgical cuff | BARAN OSTAP E | 1983-11-29 | — | — | US | disclosed |
| US-4312865-A | Medication having penetration through cutaneous surfaces into articular and muscular areas | SZUCS MURRILL M | 1982-01-26 | — | — | US | disclosed |
| US-3991755-A | IONTOPHORESIS APPARATUS FOR APPLYING LOCAL ANESTHETICS | MEDICON, INC. (US) | 1976-11-16 | — | — | US | disclosed |