Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Hexylcaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 1/20 | 0.97 |
| ▸ | SCN2A known ✓ | Q99250 | 1/20 | 0.97 |
| ▸ | SCN3A known ✓ | Q9NY46 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 7/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hexylcaine SCHEMBL24192 | 1.00 | LMNA (0.97) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL1645996 | 0.99 | LMNA (1.00) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL34239 | 0.99 | LMNA (1.00) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL34238 | 0.99 | LMNA (1.00) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Hexylcaine SCHEMBL3076544 | 0.96 | LMNA (0.95) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL14955131 | 0.78 | LMNA (0.66) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL28803763 | 0.78 | LMNA (0.65) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| Benzoic Acid SCHEMBL3676802 | 0.78 | LMNA (0.65) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL28544688 | 0.77 | LMNA (0.64) | LMNACYP1A2CYP2D6SCN1ASCN2A | |
| SCHEMBL18747647 | 0.77 | LMNA (0.64) | LMNACYP1A2CYP2D6SCN1ASCN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 558 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8691283-B2 | Standardized bee venom preparation | KIM CHRISTOPHER M (KR) | 2014-04-08 | — | — | US | claimed |
| US-20130216517-A1 | STANDARDIZED BEE VENOM PREPARATION | KIM CHRISTOPHER M (KR) | 2013-08-22 | — | — | US | claimed |
| US-8440234-B2 | Standardized bee venom preparation suitable for administration by injection comprising; Bee venom treatment without the sting | KIM CHRISTOPHER M (KR) | 2013-05-14 | — | — | US | claimed |
| CN-101754766-A | Method of pain control | GLENN ABRAHMSOHN | 2010-06-23 | — | — | CN | claimed |
| US-20090191249-A1 | Sheet substrates impregnated with aromatic releasing compositions and a method of delivery of aromatic releasing compositions | ADELAKUN OLUFEMI | 2009-07-30 | — | — | US | claimed |
| CN-1856294-A | Penetrating pharmaceutical foam | FOAMIX LTD (IL) | 2006-11-01 | — | — | CN | claimed |
| CN-1486690-A | Medicinal salt with local anesthesia and anti-inflammatory activity and preparation method thereof | ����ҩƷ��ҵ�ɷ�����˾ | 2004-04-07 | — | — | CN | claimed |
| EP-0727978-B1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | PROCTER & GAMBLE (US) | 2002-01-09 | — | — | EP | claimed |
| CN-1058150-C | Topical aromatic releasing compositions | RICHARD VICKS INC (US) | 2000-11-08 | — | — | CN | claimed |
| EP-0850054-A4 | FORMULATIONS OF HALOALKYLAMINES AND LOCAL ANAESTHETICS AND METHODS FOR THE TREATMENT OF REFLEX SYMPATHETIC DYSTROPHY (RSD) | NEW YORK MEDICAL COLLEGE (US) | 2000-09-13 | — | — | EP | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| US-5322689-A | Topical aromatic releasing compositions | THE PROCTER & GAMBLE COMPANY (US) | 1994-06-21 | — | — | US | claimed |
| WO-1994002176-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-03 | — | — | WO | claimed |
| WO-1993017655-A1 | TOPICAL AROMATIC RELEASING COMPOSITIONS | RICHARDSON VICKS INC. (US) | 1993-09-16 | — | — | WO | claimed |
| CN-1072602-A | Improve the enhanced dermal osmosis system of the local conveying of medicine | RICHARDSON VICKS INC (US) | 1993-06-02 | — | — | CN | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| EP-0351897-A2 | Skin penetration system for salts of amine-functional drugs | THE PROCTER & GAMBLE COMPANY (US) | 1990-01-24 | — | — | EP | claimed |
| US-4741899-A | Process for arresting the proliferation of organisms that convert axillary secretions to malodorous materials | BRISTOL-MYERS COMPANY (US) | 1988-05-03 | — | — | US | claimed |