Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | BCL3 | P20749 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.35 |
| ▸ | PRSS12 | P56730 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CDK1 | P06493 | 2/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1645958 | 0.84 | DHODH (0.54) | DHODH | |
| SCHEMBL1646494 | 0.83 | MAPT (0.60) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL5113349 | 0.83 | MAPT (0.39) | MAPTMEN1KMT2APOLBNPC1 | |
| SCHEMBL12252539 | 0.80 | MAPT (0.48) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL8302422 | 0.80 | MEN1 (0.41) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL1645062 | 0.80 | MAPT (0.47) | MAPTMEN1KMT2ATP53NPC1 | |
| SCHEMBL1647416 | 0.78 | L3MBTL1 (0.43) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL1645923 | 0.78 | PRSS12 (0.49) | MAPTMEN1KMT2APOLBPRSS12 | |
| SCHEMBL8305324 | 0.78 | MAPT (0.46) | MAPTMEN1KMT2APOLBNPC1 | |
| SCHEMBL1647120 | 0.78 | MAPT (0.48) | MAPTMEN1KMT2ATP53POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2305250-A1 | BENZIMIDAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASES INHIBITORS | Astex Therapeutics Limited (GB) | 2011-04-06 | — | — | EP | disclosed |