SCHEMBL1646136

SCHEMBL1646136

Clc1ccc(SSc2c(Cl)c(Br)c(Cl)c(Br)c2Cl)c(Cl)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.44
ITGB2 P05107 3/20 0.40
ICAM1 P05362 3/20 0.40
ITGAL P20701 3/20 0.40
RHEB Q15382 3/20 0.36
TP53 P04637 1/20 0.35
CYP3A4 P08684 3/20 0.32
TSHR P16473 3/20 0.32
AHR P35869 2/20 0.32
MAPK1 P28482 2/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ALDH1A1 P00352 1/20 0.31
MAPT P10636 1/20 0.31
AR P10275 1/20 0.31
MRGPRX4 Q96LA9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1647328 0.85 FBP1 (0.49) FBP1ITGB2ICAM1ITGALRHEB
SCHEMBL30472043 0.80 FBP1 (0.58) FBP1ITGB2ICAM1ITGALRHEB
SCHEMBL224671 0.80 FBP1 (0.58) FBP1ITGB2ICAM1ITGALRHEB
SCHEMBL1646615 0.78 FBP1 (0.41) FBP1RHEBTSHRMEN1KMT2A
SCHEMBL1646188 0.74 FBP1 (0.33) FBP1ALDH1A1
SCHEMBL1647015 0.69
SCHEMBL6932304 0.68 PDE7A (0.39) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL10624759 0.68 FBP1 (0.38) FBP1ITGB2ICAM1ITGALMAPK1
SCHEMBL3165346 0.67 ITGB2 (0.72) ITGB2ICAM1ITGALRHEBTP53
SCHEMBL1648142 0.66 FBP1 (0.45) FBP1ITGB2ICAM1ITGALRHEB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8426526-B2 Solid golf ball SRI SPORTS LIMITED (JP) 2013-04-23 US disclosed
US-20110086727-A1 SOLID GOLF BALL SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2011-04-14 US disclosed