SCHEMBL224671

SCHEMBL224671

Clc1ccc(SSc2ccc(Cl)cc2Cl)c(Cl)c1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FBP1 P09467 1/20 0.58
ITGB2 P05107 2/20 0.54
ICAM1 P05362 2/20 0.54
ITGAL P20701 2/20 0.54
TP53 P04637 2/20 0.52
TSHR P16473 6/20 0.46
CYP3A4 P08684 5/20 0.46
HSD17B10 Q99714 3/20 0.46
MAPK1 P28482 2/20 0.44
CYP2C9 P11712 2/20 0.44
CYP2C19 P33261 2/20 0.44
CYP1A2 P05177 1/20 0.44
MEN1 O00255 3/20 0.43
KMT2A Q03164 3/20 0.43
TDP1 Q9NUW8 3/20 0.42
RHEB Q15382 1/20 0.42
ALDH1A1 P00352 3/20 0.41
IDO1 P14902 1/20 0.41
PLA2G1B P04054 1/20 0.41
HSP90AA1 P07900 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30472043 1.00 FBP1 (0.58) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL1647328 0.87 FBP1 (0.49) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL3165346 0.83 ITGB2 (0.72) ITGB2ICAM1ITGALTP53TSHR
SCHEMBL1648142 0.82 FBP1 (0.45) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL4127172 0.81 ITGB2 (0.52) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL1646136 0.80 FBP1 (0.44) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL5044607 0.79 ITGB2 (0.55) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL10834427 0.79 ITGB2 (0.50) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL8779862 0.79 ITGB2 (0.50) FBP1ITGB2ICAM1ITGALTP53
SCHEMBL224672 0.79 ITGB2 (0.50) FBP1ITGB2ICAM1ITGALTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 629 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6998444-B2 Vulcanization accelerator in crosslinked cis-polybutadiene core for increase compression and low coefficient of restitution, without causing any isomerism; use small amounts of crosslinker zinc diacrylate ACUSHNET COMPANY (US) 2006-02-14 US claimed
US-20050256274-A1 Golf ball core compositions JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2005-11-17 US claimed
US-6960629-B2 Use of a metallic mercaptothiazole or metallic mercaptobenzothiazole in golf ball compositions ACUSHNET COMPANY (US) 2005-11-01 US claimed
US-20040230006-A1 Use of a metallic mercaptothiazole or metallic mercaptobenzothiazole in golf ball compositions JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2004-11-18 US claimed
US-20040230005-A1 Use of a metallic mercaptothiazole or metallic mercaptobenzothiazole in golf ball compositions ACUSHNET COMPANY 2004-11-18 US claimed
US-5861465-A VULCANIZED RUBBER CONTAINING A DIPHENYL AND DINAPHTHYL DISULFIDE; IMPACT STRENGTH, RESILIENCE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 1999-01-19 US claimed
CN-113387855-B Method for synthesizing disulfide compound by visible light and titanocene complex concerted catalysis 陕西师范大学 2023-04-14 CN disclosed
EP-3625225-B1 LDHA ACTIVITY INHIBITORS ARCTIC PHARMA AS (NO) 2022-06-29 EP disclosed
EP-3625225-B1 LDHA ACTIVITY INHIBITORS ARCTIC PHARMA AS (NO) 2022-06-29 EP disclosed
US-20220073817-A1 METHOD FOR PRODUCING QUANTUM DOT-CONTAINING FILM AND COMPOSITION FOR PRODUCING QUANTUM DOT-CONTAINING FILM TOKYO OHKA KOGYO CO., LTD. (JP) 2022-03-10 US disclosed
US-20220073815-A1 METHOD FOR PRODUCING QUANTUM DOT DISPERSION AND QUANTUM DOT DISPERSION TOKYO OHKA KOGYO CO., LTD. (JP) 2022-03-10 US disclosed
US-11148011-B2 Golf ball SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 2021-10-19 US disclosed
US-11142520-B2 LDHA activity inhibitors ARCTIC PHARMA AS (NO) 2021-10-12 US disclosed
US-20010024982-A1 Thin-layer-covered multilayer golf ball JPMORGAN CHASE BANK, N.A., AS SUCCESSOR ADMINISTRATIVE AGENT 2001-09-27 US disclosed
US-6291592-B1 HARDNESS, STIFFNESS ACUSHNET COMPANY 2001-09-18 US disclosed
WO-2000038794-A1 LOW COMPRESSION, RESILIENT GOLF BALLS INCLUDING AN ORGANOSULFUR CATALYST AND METHOD FOR MAKING SAME ACUSHNET COMPANY (US) 2000-07-06 WO disclosed
WO-2000038793-A1 LOW COMPRESSION, RESILIENT GOLF BALLS INCLUDING ELEMENTAL CATALYST AND METHOD FOR MAKING SAME ACUSHNET COMPANY (US) 2000-07-06 WO disclosed
WO-2000038795-A1 LOW COMPRESSION, RESILIENT GOLF BALLS INCLUDING AROMATIC CATALYST AND METHOD FOR MAKING SAME ACUSHNET COMPANY (US) 2000-07-06 WO disclosed
US-5861465-A VULCANIZED RUBBER CONTAINING A DIPHENYL AND DINAPHTHYL DISULFIDE; IMPACT STRENGTH, RESILIENCE SUMITOMO RUBBER INDUSTRIES, LTD. (JP) 1999-01-19 US disclosed
US-4399075-A Process for producing chlorinated phenoxytoluene derivatives ASAHI CHEMICAL COMPANY, LIMITED (JP) 1983-08-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11142520-B2 LDHA activity inhibitors LDHA, LDHB, PDHA1 FBP1 87/4885ITGB2 3956/4885ICAM1 1756/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.