Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | ENPP3 | O14638 | 2/20 | 0.49 |
| ▸ | ENPP1 | P22413 | 2/20 | 0.49 |
| ▸ | MMP2 | P08253 | 2/20 | 0.49 |
| ▸ | MMP9 | P14780 | 2/20 | 0.49 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4253034 | 0.95 | ENPP3 (0.55) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL6683781 | 0.95 | ENPP3 (0.55) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL12797828 | 0.82 | HSD17B1 (0.49) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL4267177 | 0.79 | PSD (0.48) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL8119305 | 0.78 | ENPP3 (0.59) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL3271684 | 0.77 | ENPP3 (0.72) | NPC1RAB9AKMT2AMEN1ENPP3 | |
| SCHEMBL11566150 | 0.77 | ENPP3 (0.72) | NPC1RAB9AKMT2AMEN1ENPP3 | |
| SCHEMBL28489642 | 0.77 | MEN1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL6731942 | 0.77 | MEN1 (0.60) | NPC1RAB9AKMT2AMEN1MAPT | |
| SCHEMBL5664564 | 0.76 | ENPP3 (0.75) | NPC1RAB9AKMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2303329-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G Limited (GB) | 2011-04-06 | — | — | EP | disclosed |
| WO-2009144473-A1 | ANTIFUNGAL COMBINATION THERAPY | F2G LIMITED (GB) | 2009-12-03 | — | — | WO | disclosed |