Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 2/20 | 0.40 |
| ▸ | HEXA | P06865 | 1/20 | 0.40 |
| ▸ | HEXB | P07686 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | BCHE | P06276 | 2/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16463309 | 0.77 | ADORA2A (0.49) | SMN1; SMN2NPC1TSHRRAB9AMAP4K4 | |
| SCHEMBL16462942 | 0.74 | TEAD4 (0.47) | SMN1; SMN2HPGDALDH1A1MEN1KMT2A | |
| SCHEMBL16463607 | 0.72 | ALDH1A1 (0.50) | ALDH1A1CYP1A2CYP2C9CYP2C19TSHR | |
| SCHEMBL24309334 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL29566842 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL24309782 | 0.70 | ADORA2A (0.47) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL127000 | 0.70 | TSHR (0.65) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL29637724 | 0.70 | TSHR (0.65) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL24287258 | 0.69 | ALDH1A1 (0.50) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 | |
| SCHEMBL9858859 | 0.69 | SMN1; SMN2 (0.59) | SMN1; SMN2HPGDALDH1A1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9364408-B2 | Hair dye agent comprising aminopyrimidine derivatives | HENKEL AG & CO. KGAA (DE) | 2016-06-14 | — | — | US | claimed |
| EP-2906191-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | Henkel AG&Co. KGAA (DE) | 2015-08-19 | — | — | EP | claimed |
| US-20150209258-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2015-07-30 | — | — | US | claimed |
| WO-2014056760-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2014-04-17 | — | — | WO | claimed |
| US-9364408-B2 | Hair dye agent comprising aminopyrimidine derivatives | HENKEL AG & CO. KGAA (DE) | 2016-06-14 | — | — | US | disclosed |
| US-9364408-B2 | Hair dye agent comprising aminopyrimidine derivatives | HENKEL AG & CO. KGAA (DE) | 2016-06-14 | — | — | US | disclosed |
| US-20150209258-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150209258-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2015-07-30 | — | — | US | disclosed |
| WO-2014056760-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150209258-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | KRT18, DPYD, DHFR | SMN1; SMN2 4835/4885HPGD 468/4885ALDH1A1 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.