Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.73 |
| ▸ | APP | P05067 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.53 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646332 | 1.00 | BACE1 (0.73) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646432 | 0.89 | APP (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1646433 | 0.89 | APP (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1648000 | 0.85 | BACE1 (1.00) | BACE1APPMAPTGSK3B | |
| SCHEMBL1647997 | 0.85 | BACE1 (1.00) | BACE1APPMAPTGSK3B | |
| SCHEMBL1648577 | 0.85 | BACE1 (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL1648575 | 0.85 | BACE1 (0.74) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL18559977 | 0.79 | HDAC8 (0.69) | BACE1APPMAPTAKR1B10AKR1B1 | |
| SCHEMBL18538447 | 0.79 | HDAC8 (0.65) | APPMAPTAKR1B10AKR1B1HDAC8 | |
| SCHEMBL9234919 | 0.78 | APP (1.00) | BACE1APPMAPTAKR1B10AKR1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |