Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 13/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 13/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5377283 | 0.77 | MKNK1 (0.51) | MKNK1MKNK2KCNH2ATMBTK | |
| SCHEMBL16463960 | 0.77 | MKNK1 (0.48) | MKNK1MKNK2KCNH2ATMBTK | |
| SCHEMBL16463132 | 0.77 | MKNK1 (0.48) | MKNK1MKNK2 | |
| SCHEMBL28258123 | 0.74 | MKNK1 (0.72) | MKNK1MKNK2KCNH2ATMSIRT3 | |
| SCHEMBL6237449 | 0.74 | MKNK1 (0.62) | MKNK1MKNK2SIRT3TDP1BTK | |
| SCHEMBL30338479 | 0.73 | MKNK1 (0.67) | MKNK1MKNK2KCNH2ATMBTK | |
| SCHEMBL16463459 | 0.72 | MKNK1 (0.41) | MKNK1MKNK2KCNH2ATMSIRT3 | |
| SCHEMBL30702229 | 0.71 | MKNK1 (0.59) | MKNK1MKNK2SIRT3TDP1BTK | |
| SCHEMBL30702237 | 0.71 | MKNK1 (0.59) | MKNK1MKNK2SIRT3TDP1BTK | |
| SCHEMBL6237458 | 0.71 | MKNK1 (0.58) | MKNK1MKNK2SIRT3TDP1BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200054630-A1 | BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION | MINDIMMUNE THERAPEUTICS, INC. | 2020-02-20 | — | — | US | disclosed |
| US-10238654-B2 | Benzamides-containing compounds and their use in the treatment of epilepsy | MINDIMMUNE THERAPEUTICS, INC. (US) | 2019-03-26 | — | — | US | disclosed |
| US-20170202836-A1 | Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy | H. LUNDBECK A/S (DK) | 2017-07-20 | — | — | US | disclosed |
| US-9649308-B2 | Benzamide-containing compounds and their use in the treatment of pain | H. LUNDBECK A/S (DK) | 2017-05-16 | — | — | US | disclosed |
| US-20150283134-A1 | Benzamides | MINDIMMUNE THERAPEUTICS, INC. | 2015-10-08 | — | — | US | disclosed |
| EP-2906546-A1 | BENZAMIDES | H. Lundbeck A/S (DK) | 2015-08-19 | — | — | EP | disclosed |
| US-9102591-B2 | Benzamides | H. LUNDBECK A/S (DK) | 2015-08-11 | — | — | US | disclosed |
| WO-2014057078-A1 | BENZAMIDES | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | WO | disclosed |
| US-20140107340-A1 | Benzamides | H. LUNDBECK A/S (DK) | 2014-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200054630-A1 | BENZAMIDES-CONTAINING COMPOUNDS AND THEIR USE IN THE TREATMENT OF DEPRESSION | P2RX5, P2RX7, P2RX2 | MKNK1 4434/4885MKNK2 4014/4885KCNH2 162/4885 |
| US-20140107340-A1 | Benzamides | P2RX7, TRPV1, P2RX5 | MKNK1 4616/4885MKNK2 4281/4885KCNH2 285/4885 |
| US-10238654-B2 | Benzamides-containing compounds and their use in the treatment of epilepsy | P2RX5, P2RX7, P2RX6 | MKNK1 4447/4885MKNK2 4035/4885KCNH2 98/4885 |
| US-20170202836-A1 | Benzamides-Containing Compounds and Their Use in the Treatment of Epilepsy | P2RX5, P2RX7, P2RX6 | MKNK1 4447/4885MKNK2 4035/4885KCNH2 98/4885 |
| US-20150283134-A1 | Benzamides | P2RX7, TRPV1, P2RX5 | MKNK1 4616/4885MKNK2 4281/4885KCNH2 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.