Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A13 | Q16696 | 6/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27081642 | 0.86 | KDM4E (0.48) | ALDH1A1KDM4EATMKMT2APOLB | |
| SCHEMBL1655534 | 0.82 | ALDH1A1 (0.46) | CYP2C9ALDH1A1KDM4EATMKMT2A | |
| SCHEMBL28001279 | 0.82 | KDM4E (0.42) | ALDH1A1KDM4EATMKMT2AHRH3 | |
| SCHEMBL989375 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KDM4EATMKMT2APOLB | |
| SCHEMBL16462153 | 0.80 | CYP2A13 (0.61) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL27677146 | 0.79 | ALDH1A1 (0.52) | ALDH1A1KDM4EATMKMT2APOLB | |
| SCHEMBL15859936 | 0.78 | KDM4E (0.67) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL16462107 | 0.77 | CYP2A13 (0.61) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL7446492 | 0.77 | CYP2A13 (0.61) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 | |
| SCHEMBL296307 | 0.75 | CYP2A13 (0.63) | CYP2A13CYP2C9ALOX15HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8629168-B2 | Benzoxazoles and oxazolopyridines being useful as janus kinases inhibitors | NOVARTIS AG (CH) | 2014-01-14 | — | — | US | claimed |
| CN-101516860-B | Benzoxazoles and oxazolopyridines being useful as FANUS kinases inhibitors | NOVARTIS AG | 2012-06-27 | — | — | CN | claimed |