Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 3/20 | 0.61 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 11/20 | 0.44 |
| ▸ | DAPK1 | P53355 | 3/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.44 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.44 |
| ▸ | MYLK2 | Q9H1R3 | 3/20 | 0.44 |
| ▸ | GAK | O14976 | 3/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.44 |
| ▸ | CIT | O14578 | 2/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.44 |
| ▸ | TLK2 | Q86UE8 | 1/20 | 0.44 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.44 |
| ▸ | TLK1 | Q9UKI8 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20377802 | 0.85 | PIK3C3 (0.49) | IRAK4TGFBR1CNR2PIK3C3 | |
| SCHEMBL16898714 | 0.84 | IRAK4 (0.45) | IRAK4ATRGSK3BDYRK1ACYP3A4 | |
| SCHEMBL1857045 | 0.79 | ALDH1A1 (0.48) | ATRDYRK1ACYP3A4 | |
| SCHEMBL2080592 | 0.79 | IRAK4 (0.43) | IRAK4TGFBR1AAK1DAPK1MKNK2 | |
| SCHEMBL31268286 | 0.79 | IRAK4 (0.43) | IRAK4TGFBR1AAK1DAPK1MKNK2 | |
| SCHEMBL24150715 | 0.78 | PLAU (0.43) | IRAK4CNR2 | |
| SCHEMBL5548970 | 0.78 | ATR (0.48) | IRAK4AAK1ATRPIK3C3GSK3B | |
| SCHEMBL5251219 | 0.77 | EGFR (0.57) | IRAK4TGFBR1AAK1PIK3C3GSK3B | |
| SCHEMBL16482170 | 0.77 | IRAK4 (1.00) | IRAK4KCNH2 | |
| SCHEMBL16116222 | 0.76 | PIK3C3 (0.45) | IRAK4TGFBR1AAK1ATRPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903613-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2017-11-22 | — | — | EP | disclosed |
| EP-2903613-B1 | PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2017-11-22 | — | — | EP | disclosed |
| US-9586948-B2 | Inhibitors of IRAK4 activity | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-9586948-B2 | Inhibitors of IRAK4 activity | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |
| US-20150274708-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | US | disclosed |
| US-20150274708-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2015-10-01 | — | — | US | disclosed |
| EP-2903613-A1 | INHIBITORS OF IRAK4 ACTIVITY | Merck Sharp & Dohme Corp. (US) | 2015-08-12 | — | — | EP | disclosed |
| WO-2014058691-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014058691-A1 | INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150274708-A1 | INHIBITORS OF IRAK4 ACTIVITY | IRAK4, IRAK2, IRAK1 | IRAK4 1/4885TGFBR1 561/4885AAK1 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.