Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16465331 | 0.77 | GAA (0.45) | KMT2AGAAMEN1POLBKDM4E | |
| SCHEMBL4559594 | 0.77 | CXCL12 (0.44) | KMT2AGAAMEN1PLAUPOLB | |
| SCHEMBL13826194 | 0.76 | PDPK1 (0.37) | KMT2AMEN1POLBKDM4EALDH1A1 | |
| SCHEMBL18351964 | 0.76 | DHODH (0.43) | KMT2AGAAMEN1KDM4EDHODH | |
| SCHEMBL15621840 | 0.76 | CYP1A2 (0.51) | KMT2AGAAMEN1PLAUPOLB | |
| SCHEMBL15621964 | 0.73 | NPC1 (0.50) | KMT2AGAAMEN1IKBKBSMN1; SMN2 | |
| SCHEMBL15069721 | 0.71 | KDR (0.64) | KMT2AGAAMEN1POLBKDM4E | |
| SCHEMBL1612494 | 0.71 | IKBKB (0.48) | KMT2AGAAMEN1POLBKDM4E | |
| SCHEMBL14917472 | 0.70 | CDC7 (0.45) | KMT2AGAAMEN1POLBKDM4E | |
| SCHEMBL14917475 | 0.70 | IKBKB (0.51) | KMT2AGAAMEN1PLAUKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903970-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | claimed |
| WO-2014058921-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | claimed |