Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 10/20 | 0.45 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 9/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | MAP2K3 | P46734 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4559639 | 0.78 | ADORA2A (0.39) | GAAMEN1KMT2AADORA2ANUDT1 | |
| SCHEMBL16465321 | 0.77 | KMT2A (0.45) | GAAMEN1KMT2ACDC7POLB | |
| SCHEMBL4559785 | 0.76 | ADORA2A (0.47) | GAAMEN1KMT2AADORA2ANUDT1 | |
| SCHEMBL4559145 | 0.76 | ADORA2A (0.56) | GAAMEN1KMT2AADORA2ANUDT1 | |
| SCHEMBL15621844 | 0.76 | MPO (0.43) | GAAMEN1KMT2AADORA2ANUDT1 | |
| SCHEMBL18351967 | 0.73 | ADORA2A (0.44) | GAAMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL15621967 | 0.73 | DHFR (0.52) | GAAMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL28145391 | 0.73 | ADORA2A (0.59) | ADORA2ANUDT1ADORA1POLBADORA2B | |
| SCHEMBL4559176 | 0.71 | SIRT2 (0.45) | GAAMEN1KMT2AADORA2AADORA1 | |
| SCHEMBL14917472 | 0.70 | CDC7 (0.45) | GAAMEN1KMT2AADORA1CDC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903970-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | Portola Pharmaceuticals, Inc. (US) | 2015-08-12 | — | — | EP | claimed |
| WO-2014058921-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2014-04-17 | — | — | WO | claimed |