Sorgoleone-364

Sorgoleone-364

SCHEMBL16465702

CCCCCCCCCCCCCC1=C(O)C(=O)C=C(OC)C1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 17/20 1.00
MPEG1 Q2M385 8/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
5-O-Methylembelin SCHEMBL31152617 1.00 ALOX5 (1.00) ALOX5MPEG1
SCHEMBL9578683 0.94 ALOX5 (0.88) ALOX5MPEG1
SCHEMBL9578885 0.92 ALOX5 (0.85) ALOX5MPEG1
SCHEMBL31040566 0.92 ALOX5 (0.85) ALOX5MPEG1
SCHEMBL9578879 0.92 ALOX5 (0.85) ALOX5MPEG1
SCHEMBL9226380 0.89 ALOX5 (0.80) ALOX5MPEG1
SCHEMBL5179329 0.89 ALOX5 (0.80) ALOX5MPEG1
SCHEMBL9578710 0.89 ALOX5 (0.80) ALOX5MPEG1
SCHEMBL9226377 0.89 ALOX5 (0.80) ALOX5MPEG1
SCHEMBL9578717 0.89 ALOX5 (0.80) ALOX5MPEG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9957214-B2 Multifunctional radical quenchers ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-05-01 US disclosed
US-9957214-B2 Multifunctional radical quenchers ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2018-05-01 US disclosed
US-20150274628-A1 MULTIFUNCTIONAL RADICAL QUENCHERS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-10-01 US disclosed
US-20150274628-A1 MULTIFUNCTIONAL RADICAL QUENCHERS ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2015-10-01 US disclosed
EP-2906207-A1 MULTIFUNCTIONAL RADICAL QUENCHERS Arizona Board of Regents on behalf of Arizona State University (US) 2015-08-19 EP disclosed
WO-2014059158-A1 MULTIFUNCTIONAL RADICAL QUENCHERS ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2014-04-17 WO disclosed
WO-2014059158-A1 MULTIFUNCTIONAL RADICAL QUENCHERS ARIZONA BOARD OF REGENTS, A BODY CORPORATE OF THE STATE OF ARIZONA, ACTING FOR AN ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2014-04-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150274628-A1 MULTIFUNCTIONAL RADICAL QUENCHERS SQOR, UQCRC1, PRDX5 ALOX5 779/4885MPEG1 2716/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.