Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | BLM | P54132 | 3/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.62 |
| ▸ | HTR7 | P34969 | 1/20 | 0.62 |
| ▸ | HTR2B | P41595 | 1/20 | 0.62 |
| ▸ | MTOR | P42345 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16465829 | 1.00 | HTR1A (0.62) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11385676 | 0.96 | HTR1A (0.64) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11385677 | 0.96 | HTR1A (0.64) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11378336 | 0.92 | HTR1A (0.67) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11378338 | 0.92 | HTR1A (0.67) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11380186 | 0.87 | HTR1A (0.70) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL11380183 | 0.87 | HTR1A (0.70) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL7449327 | 0.85 | HTR1A (0.68) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL27990793 | 0.85 | HTR1A (0.68) | HTR1AKMT2ABLMKDM4ELMNA | |
| SCHEMBL8250982 | 0.84 | HTR1A (0.60) | HTR1AKMT2ABLMKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11261219-B2 | Proteolytic inactivation of select proteins in bacterial extracts for improved expression | SUTRO BIOPHARMA, INC. (US) | 2022-03-01 | — | — | US | disclosed |
| US-20200062807-A1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | SUTRO BIOPHARMA, INC. | 2020-02-27 | — | — | US | disclosed |
| US-10450353-B2 | Proteolytic inactivation of select proteins in bacterial extracts for improved expression | SUTRO BIOPHARMA, INC. (US) | 2019-10-22 | — | — | US | disclosed |
| EP-2906592-B1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | SUTRO BIOPHARMA INC (US) | 2018-10-03 | — | — | EP | disclosed |
| US-20170283469-A1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | SUTRO BIOPHARMA, INC. | 2017-10-05 | — | — | US | disclosed |
| US-9650621-B2 | Proteolytic inactivation of select proteins in bacterial extracts for improved expression | SUTRO BIOPHARMA, INC. (US) | 2017-05-16 | — | — | US | disclosed |
| US-20150259664-A1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | SUTRO BIOPHARMA, INC. | 2015-09-17 | — | — | US | disclosed |
| EP-2906592-A1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | Sutro Biopharma, Inc. (US) | 2015-08-19 | — | — | EP | disclosed |
| CN-104837863-A | Proteolytic inactivation of selected proteins in bacterial extracts for enhanced expression | SUTRO BIOPHARMA INC | 2015-08-12 | — | — | CN | disclosed |
| WO-2014058830-A1 | PROTEOLYTIC INACTIVATION OF SELECT PROTEINS IN BACTERIAL EXTRACTS FOR IMPROVED EXPRESSION | SUTRO BIOPHARMA, INC. (US) | 2014-04-17 | — | — | WO | disclosed |