Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.60 |
| ▸ | HTR1D | P28221 | 3/20 | 0.55 |
| ▸ | HTR1B | P28222 | 3/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.49 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | BLM | P54132 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11385676 | 0.88 | HTR1A (0.64) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL11385677 | 0.88 | HTR1A (0.64) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL16465829 | 0.84 | HTR1A (0.62) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL16465828 | 0.84 | HTR1A (0.62) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL10778563 | 0.82 | HTR1A (0.74) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL11378336 | 0.80 | HTR1A (0.67) | HTR1AHTR1DHTR1BKDM4EMAPT | |
| SCHEMBL11378338 | 0.80 | HTR1A (0.67) | HTR1AHTR1DHTR1BKDM4EMAPT | |
| SCHEMBL5471393 | 0.80 | HTR1A (0.70) | HTR1AHTR1DHTR1BGABRA1GABRB2 | |
| SCHEMBL29018529 | 0.80 | HTR1A (0.78) | HTR1AHTR1DHTR1BKDM4EMAPT | |
| SCHEMBL3037728 | 0.78 | HTR1D (0.57) | HTR1AHTR1DHTR1BGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0991645-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Roche Diagnostics GmbH (DE) | 2000-04-12 | — | — | EP | disclosed |
| WO-1999000381-A1 | BIS-INDOLE DERIVATIVES HAVING ANTIMETASTATIC ACTIVITY, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | ROCHE DIAGNOSTICS GMBH (DE) | 1999-01-07 | — | — | WO | disclosed |