Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CASP3 | P42574 | 4/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MDM4 | O15151 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732417 | 0.87 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL1343999 | 0.87 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL4287694 | 0.87 | KMT2A (0.53) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL22923671 | 0.87 | KMT2A (0.56) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL3267363 | 0.85 | KMT2A (0.54) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL6779154 | 0.85 | CASP3 (0.57) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL3470475 | 0.85 | CASP3 (0.57) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL29401008 | 0.85 | CASP3 (0.57) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL9376602 | 0.85 | CASP3 (0.57) | KMT2ACASP3EPHX2MDM4TP53 | |
| SCHEMBL2625076 | 0.84 | KMT2A (0.58) | KMT2ACASP3EPHX2MDM4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2906559-A1 | AZAINDOLINES | F. Hoffmann-La Roche AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| EP-2906535-A1 | INDOLINES | F. Hoffmann-La Roche AG (CH) | 2015-08-19 | — | — | EP | disclosed |
| WO-2014056755-A1 | INDOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-17 | — | — | WO | disclosed |
| WO-2014056871-A1 | AZAINDOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-04-17 | — | — | WO | disclosed |