Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | TERT | O14746 | 3/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.50 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.50 |
| ▸ | IP6K1 | Q92551 | 3/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.46 |
| ▸ | PRKDC | P78527 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15474866 | 0.85 | ALDH1A1 (0.50) | ALDH1A1SMN1; SMN2KDM4EMAPTMEN1 | |
| SCHEMBL15475184 | 0.83 | ALDH1A1 (0.56) | ALDH1A1SMN1; SMN2KDM4EPIK3CDPIK3CA | |
| SCHEMBL1647993 | 0.83 | PIK3CD (0.48) | ALDH1A1SMN1; SMN2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL15474510 | 0.83 | PIK3CD (0.68) | ALDH1A1SMN1; SMN2KDM4EPIK3CDPIK3CA | |
| SCHEMBL31494973 | 0.83 | CHRNB2 (0.49) | ALDH1A1KDM4EPIK3CDPIK3CAPIK3CB | |
| SCHEMBL23932966 | 0.79 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4ETERTTRIM24 | |
| SCHEMBL159816 | 0.79 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2KDM4ETERTTRIM24 | |
| SCHEMBL14941727 | 0.79 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2KDM4ETERTTRIM24 | |
| SCHEMBL11297084 | 0.79 | PIK3CD (0.71) | ALDH1A1SMN1; SMN2KDM4ETERTTRIM24 | |
| SCHEMBL1647156 | 0.77 | DRD4 (0.50) | ALDH1A1KDM4EMAPTCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10577356-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2020-03-03 | — | — | US | disclosed |
| US-20190040045-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2019-02-07 | — | — | US | disclosed |
| US-10118914-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2018-11-06 | — | — | US | disclosed |
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2017-06-15 | — | — | US | disclosed |
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2017-06-15 | — | — | US | disclosed |
| WO-2015195486-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | THE UNIVERSITY OF NORTH CAROLINA AT GREENSBORO (US) | 2015-12-23 | — | — | WO | disclosed |
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| CN-102046575-A | Therapeutic agent for alzheimer's disease | TOKYO INST TECH | 2011-05-04 | — | — | CN | disclosed |
| US-20110082295-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2011-04-07 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170166554-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | CNR1, CNR2, ARRB1 | ALDH1A1 2372/4885SMN1; SMN2 4038/4885KDM4E 2701/4885 |
| US-10577356-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | CNR1, CNR2, ARRB1 | ALDH1A1 2372/4885SMN1; SMN2 4038/4885KDM4E 2701/4885 |
| US-10118914-B2 | Beta-arrestin-biased cannabinoid CB1 receptor agonists and methods for making and using them | CNR1, CNR2, ARRB1 | ALDH1A1 2372/4885SMN1; SMN2 4038/4885KDM4E 2701/4885 |
| US-20110082295-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | ALDH1A1 683/4885SMN1; SMN2 760/4885KDM4E 1786/4885 |
| US-20190040045-A1 | BETA-ARRESTIN-BIASED CANNABINOID CB1 RECEPTOR AGONISTS AND METHODS FOR MAKING AND USING THEM | CNR1, CNR2, ARRB1 | ALDH1A1 2372/4885SMN1; SMN2 4038/4885KDM4E 2701/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.