Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 4/20 | 0.59 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | CCNK | O75909 | 1/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.48 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.48 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.46 |
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22510634 | 0.79 | CYP19A1 (0.82) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL29275462 | 0.79 | CYP19A1 (0.66) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL28907313 | 0.78 | CYP19A1 (0.64) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL29275460 | 0.78 | EPHB4 (0.70) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL13734665 | 0.77 | CYP19A1 (0.59) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL29065641 | 0.77 | CYP19A1 (0.72) | CYP19A1FLT3GSK3BNPC1RAB9A | |
| SCHEMBL14859694 | 0.77 | GSK3B (0.59) | CYP19A1FLT3GSK3BNPC1RAB9A | |
| SCHEMBL13880426 | 0.76 | CYP19A1 (0.57) | CYP19A1FLT3GSK3BCCNKCDK12 | |
| SCHEMBL1647353 | 0.76 | BACE1 (0.60) | PTGS2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL1647351 | 0.76 | BACE1 (0.60) | PTGS2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102046575-B | Therapeutic agent for alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2014-10-29 | — | — | CN | disclosed |
| US-8552220-B2 | Therapeutic agent for Alzheimer's disease | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2013-10-08 | — | — | US | disclosed |
| CN-102046575-A | Therapeutic agent for alzheimer's disease | TOKYO INST TECH | 2011-05-04 | — | — | CN | disclosed |
| US-20110082295-A1 | NOVEL CURCUMIN DERIVATIVE | TOKYO INSTITUTE OF TECHNOLOGY (JP) | 2011-04-07 | — | — | US | disclosed |
| EP-2305629-A1 | THERAPEUTIC AGENT FOR ALZHEIMER'S DISEASE | Tokyo Institute of Technology (JP) | 2011-04-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110082295-A1 | NOVEL CURCUMIN DERIVATIVE | BACE1, APP, BACE2 | CYP19A1 2154/4885FLT3 4562/4885GSK3B 1197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.