Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 13/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GSR | P00390 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16470635 | 0.92 | MAPT (0.40) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL16469705 | 0.92 | TXNRD1 (0.43) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL29371318 | 0.92 | TXNRD1 (0.43) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL28454828 | 0.91 | POLB (0.41) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL28463013 | 0.89 | TXNRD1 (0.44) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL28448816 | 0.85 | TXNRD1 (0.39) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL16470345 | 0.85 | MAPT (0.42) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL16470338 | 0.84 | MAPT (0.40) | TXNRD1MAPTGSRKDM4EMEN1 | |
| SCHEMBL16469751 | 0.83 | MAPT (0.41) | TXNRD1MAPTKDM4EMEN1LMNA | |
| SCHEMBL14444940 | 0.82 | TXNRD1 (0.55) | TXNRD1MAPTGSRJAK2S1PR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9386769-B2 | Thiazole methylamino pyridine compounds and preparation method therefor | HUNAN RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2016-07-12 | — | — | US | claimed |
| US-20150051402-A1 | Thiazole Methylamino Pyridine Compounds and Preparation Method Therefor | HUNAN RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD. (CN) | 2015-02-19 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051402-A1 | Thiazole Methylamino Pyridine Compounds and Preparation Method Therefor | NOTUM, WEE1, CYP51A1 | TXNRD1 1289/4885MAPT 2642/4885GSR 157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.