⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3787961 | 0.78 | FDPS (0.47) | — | |
| SCHEMBL8671012 | 0.78 | FDPS (0.47) | — | |
| SCHEMBL27260 | 0.74 | — | — | |
| SCHEMBL3858709 | 0.74 | — | — | |
| SCHEMBL155115 | 0.74 | — | — | |
| SCHEMBL167744 | 0.74 | — | — | |
| SCHEMBL244256 | 0.74 | — | — | |
| SCHEMBL1680330 | 0.74 | — | — | |
| SCHEMBL1266275 | 0.74 | — | — | |
| SCHEMBL1151196 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107921138-A | Therapeutic alliance including giving 2 amino, 3,5,5 trifluoro, 3,4,5,6 tetrahydropyridine | H.隆德贝克有限公司 | 2018-04-17 | — | — | CN | claimed |
| US-20060014796-A1 | Epothilone derivatives | DENNI-DISCHERT DONATIENNE | 2006-01-19 | — | — | US | claimed |
| EP-1581536-A2 | EPOTHILONE DERIVATIVES | Novartis AG (CH) | 2005-10-05 | — | — | EP | claimed |
| WO-2004056832-A2 | EPOTHILONE DERIVATIVES | NOVARTIS AG (CH) | 2004-07-08 | — | — | WO | claimed |
| EP-0248735-B1 | 2-Thiazolyl imidazo [1,2-a] pyrimidines and their salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1990-05-23 | — | — | EP | claimed |
| CN-106029639-B | Treat 2- amino -3,5 of the BACE1 inhibitor of Alzheimer disease, 5- tri- fluoro- 3,4,5,6- tetrahydropyridines | H.隆德贝克有限公司 | 2019-01-08 | — | — | CN | disclosed |
| CN-104271571-B | Tetrazolinone compound and use thereof | 住友化学株式会社 | 2017-07-07 | — | — | CN | disclosed |
| US-20110098326-A1 | 2-FLUOROTHIAZOLE DERIVATIVES USEFUL AS IMAGING AGENTS; METHODS OF SYNTHESIS, AND METHODS OF USE | THE GOV. OF THE U.S.A. AS REPRESENTED BY THE SECRETARY OF THE DEPT. OF HEALTH AND HUMAN SERVICES | 2011-04-28 | — | — | US | disclosed |
| WO-2010063487-A1 | PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2010-06-10 | — | — | WO | disclosed |
| US-7317100-B2 | Epothilone derivatives | NOVARTIS AG (CH) | 2008-01-08 | — | — | US | disclosed |
| EP-1765795-A2 | ALKYNYL DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Addex Pharmaceuticals SA (CH) | 2007-03-28 | — | — | EP | disclosed |
| US-20060014796-A1 | Epothilone derivatives | DENNI-DISCHERT DONATIENNE | 2006-01-19 | — | — | US | disclosed |
| WO-2004056832-A2 | EPOTHILONE DERIVATIVES | NOVARTIS AG (CH) | 2004-07-08 | — | — | WO | disclosed |
| WO-2003016311-A1 | TRICYCLIC PYRIDIN-2-ONE ANALOGUES AS LIGANDS FOR GABA-A RECEPTORS | MERCK SHARP & DOHME LIMITED (GB) | 2003-02-27 | — | — | WO | disclosed |
| EP-0607795-B1 | Process for the preparation of 2-alkyl-4-fluoromethyl-thiazole-carboxylic acid esters | BASF AG (DE) | 1995-10-04 | — | — | EP | disclosed |
| EP-0607795-A1 | Process for the preparation of 2-alkyl-4-fluoromethyl-thiazole-carboxylic acid esters | BASF Aktiengesellschaft (DE) | 1994-07-27 | — | — | EP | disclosed |
| US-4586948-A | 2,4-disubstituted-5-thiazole-carboxylic acids and derivatives | MONSANTO COMPANY (US) | 1986-05-06 | — | — | US | disclosed |
| US-4437876-A | PLANT SAFENING AGENTS FOR ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4437875-A | PLANT SAFENING AGENT FOR ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4199506-A | REDUCES HERBICIDAL INJURY TO PLATNS DUE TO ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1980-04-22 | — | — | US | disclosed |