Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.50 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646590 | 0.88 | LRRK2 (0.58) | LRRK2PTGER1CCR5MRGPRX4LMNA | |
| SCHEMBL1647367 | 0.81 | LRRK2 (0.59) | LRRK2PTGER1LMNAHTTKMT2A | |
| SCHEMBL1646587 | 0.78 | LRRK2 (0.60) | LRRK2LMNAMAPT | |
| SCHEMBL1647514 | 0.77 | LRRK2 (0.61) | LRRK2PTGER1CCR5MRGPRX4LMNA | |
| SCHEMBL1648521 | 0.76 | LRRK2 (0.56) | LRRK2PTGER1CCR5LMNAKMT2A | |
| SCHEMBL1647430 | 0.75 | LRRK2 (0.60) | LRRK2PTGER1CCR5 | |
| SCHEMBL1646798 | 0.74 | CCR5 (0.58) | LRRK2CCR5ALDH1A1 | |
| SCHEMBL552025 | 0.73 | LRRK2 (0.57) | LRRK2LMNAHTTFOLH1ALDH1A1 | |
| SCHEMBL1648089 | 0.73 | LMNA (0.46) | LRRK2CCR5MRGPRX4LMNAHTT | |
| SCHEMBL1648028 | 0.73 | MEN1 (0.52) | LRRK2PTGER1CCR5KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483254-A1 | NOVEL COMPOUNDS | Glaxo Group Limited (GB) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011038572-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2011-04-07 | — | — | WO | disclosed |