Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
| ▸ | HTR2C | P28335 | 3/20 | 0.42 |
| ▸ | HTR2B | P41595 | 3/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18324644 | 0.83 | MAOB (0.42) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL16474303 | 0.83 | JAK2 (0.44) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL4289083 | 0.81 | MAOB (0.45) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL16474198 | 0.81 | KDM4E (0.39) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL17772163 | 0.81 | MAOB (0.40) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL4105082 | 0.77 | MAOB (0.39) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL17772162 | 0.76 | RIPK1 (0.50) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL19275745 | 0.74 | RIPK1 (0.58) | MAOBMAOARIPK1 | |
| SCHEMBL17772171 | 0.72 | KDM1A (0.47) | KDM1ARCOR1HTR2AHTR2CHTR2B | |
| SCHEMBL18783105 | 0.72 | LMNA (0.56) | KDM1ARCOR1MAOBMAOARIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2725028-B1 | Substituted pyrazolo[1,5-]pyrimidine compounds as intermediates in the synthesis of TRK kinase inhibitors | ARRAY BIOPHARMA INC (US) | 2016-05-25 | — | — | EP | disclosed |
| EP-2350071-B1 | SUBSTITUTED PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS TRK KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2014-01-08 | — | — | EP | disclosed |