Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 6/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.41 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16476552 | 0.94 | GPR119 (0.47) | PDE4BGPR119USP30BRD3PIK3CD | |
| SCHEMBL2409130 | 0.85 | PDE4B (0.49) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL2409128 | 0.85 | PDE4B (0.49) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL2412041 | 0.85 | PDE4B (0.49) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL15057701 | 0.84 | PDE4B (0.51) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL15057700 | 0.84 | PDE4B (0.51) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL15058691 | 0.84 | PDE4B (0.48) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL16476504 | 0.84 | PDE4B (0.48) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL15058693 | 0.84 | PDE4B (0.48) | PDE4BCHEK2GPR119SCN9AUSP30 | |
| SCHEMBL5371739 | 0.83 | PDE4B (0.52) | PDE4BCHEK2GPR119USP30BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539346-B1 | 4-[HETEROCYCLOALKYLOXY(HETERO)ARYLAMINO] THIENO[2,3-D]PYRIMIDINES HAVING MNK1/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2014-04-16 | — | — | EP | disclosed |