Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.43 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16476646 | 0.94 | PDE4B (0.48) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL23161336 | 0.87 | GPR119 (0.53) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL23161334 | 0.87 | GPR119 (0.53) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL15696667 | 0.86 | GPR119 (0.49) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL2409370 | 0.85 | HDAC1 (0.52) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL2409365 | 0.85 | HDAC1 (0.52) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL3112184 | 0.83 | RBP4 (0.59) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL12319153 | 0.82 | GPR119 (0.48) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL2407380 | 0.81 | GPR119 (0.48) | GPR119PDE4BUSP30PIK3CDPIK3CA | |
| SCHEMBL2407379 | 0.81 | GPR119 (0.48) | GPR119PDE4BUSP30PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2539346-B1 | 4-[HETEROCYCLOALKYLOXY(HETERO)ARYLAMINO] THIENO[2,3-D]PYRIMIDINES HAVING MNK1/ MNK2 INHIBITING ACTIVITY FOR PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM INT (DE) | 2014-04-16 | — | — | EP | disclosed |