Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 8/20 | 0.38 |
| ▸ | CTSK | P43235 | 4/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | WNT1 | P04628 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16478224 | 0.88 | CTSC (0.36) | CTSCCTSKMAPK1 | |
| SCHEMBL289966 | 0.84 | CTSC (0.54) | CTSCCTSK | |
| SCHEMBL16478361 | 0.82 | CTSK (0.35) | CTSCCTSKCYP11B2 | |
| SCHEMBL290330 | 0.79 | CTSC (0.38) | CTSCCTSKMAPK1 | |
| SCHEMBL16478185 | 0.79 | RET (0.40) | CTSCCTSKMAPK1 | |
| SCHEMBL16478162 | 0.77 | KCNH2 (0.32) | CTSCCTSKCYP11B2 | |
| SCHEMBL16478365 | 0.75 | F9 (0.39) | CTSCCTSKGSK3BMAPK1 | |
| SCHEMBL2890767 | 0.71 | CTSC (0.74) | CTSCCTSK | |
| SCHEMBL2890772 | 0.71 | CTSC (0.74) | CTSCCTSK | |
| SCHEMBL289965 | 0.71 | CTSC (0.39) | CTSCCTSKCYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011154677-A1 | SUBSTITUTED N-[1-CYANO-2-(PHENYL)ETHYL] 1-AMINOCYCLOALK-1-YLCARBOXAMIDE COMPOUNDS - 760 | ASTRAZENECA AB (SE) | 2011-12-15 | — | — | WO | disclosed |