Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.52 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RAD51 | Q06609 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | PDK1 | Q15118 | 3/20 | 0.36 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16480395 | 0.88 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3ABL1PARP1 | |
| SCHEMBL9892990 | 0.86 | ABL1 (0.44) | SLC6A2SLC6A4SLC6A3ABL1HDAC1 | |
| SCHEMBL16480476 | 0.86 | SLC6A2 (0.68) | SLC6A2SLC6A4SLC6A3ABL1 | |
| SCHEMBL16480426 | 0.84 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ABL1MMP2 | |
| SCHEMBL9893163 | 0.84 | CCR1 (0.45) | SLC6A2SLC6A4SLC6A3ABL1HDAC1 | |
| SCHEMBL16542459 | 0.82 | ABL1 (0.44) | SLC6A2SLC6A4SLC6A3ABL1HDAC1 | |
| SCHEMBL9891766 | 0.82 | IDO1 (0.38) | SLC6A2SLC6A4SLC6A3HDAC1HDAC8 | |
| SCHEMBL16480404 | 0.81 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3ABL1 | |
| SCHEMBL9893055 | 0.81 | PARP1 (0.43) | SLC6A2SLC6A4SLC6A3ABL1HDAC1 | |
| SCHEMBL16480418 | 0.80 | HTR7 (0.43) | SLC6A2SLC6A4SLC6A3ABL1HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2384320-B1 | PYRROLIDINE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR | BOEHRINGER INGELHEIM INT (DE) | 2015-03-04 | — | — | EP | disclosed |
| US-8629157-B2 | Pyrrolidine compounds which modulate the CB2 receptor | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-01-14 | — | — | US | disclosed |