Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 6/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MPO | P05164 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
| ▸ | TUBB | P07437 | 1/20 | 0.31 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.31 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.31 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.31 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.31 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.31 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.31 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20261964 | 0.93 | TLR7 (0.35) | GRIN2BCASRKMT2ATLR7MAPT | |
| SCHEMBL16386429 | 0.85 | TLR7 (0.45) | GRIN2BCASRTLR7 | |
| SCHEMBL19661033 | 0.84 | GRM2 (0.35) | TLR7TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL20996056 | 0.81 | EGFR (0.33) | KMT2AHPGD | |
| SCHEMBL18359327 | 0.80 | CYP19A1 (0.33) | TLR7 | |
| SCHEMBL29101651 | 0.79 | GLA (0.32) | — | |
| SCHEMBL3506358 | 0.78 | FGFR1 (0.39) | GRIN2BKMT2AMEN1MAPTHPGD | |
| SCHEMBL19661102 | 0.78 | NUDT1 (0.35) | TLR7 | |
| SCHEMBL15600306 | 0.77 | HDAC1 (0.42) | MAPTCNR2 | |
| SCHEMBL20996061 | 0.77 | MAPT (0.41) | MAPTCNR2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11220504-B2 | Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases | Janssen Sciences Ireland Unlimited Company (IE) | 2022-01-11 | — | — | US | disclosed |
| US-20190330217-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | Janssen Sciences Ireland Unlimited Company (IE) | 2019-10-31 | — | — | US | disclosed |
| US-10259814-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2019-04-16 | — | — | US | disclosed |
| EP-2906563-B1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN SCIENCES IRELAND UC (IE) | 2018-02-28 | — | — | EP | disclosed |
| US-20170044169-A1 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-16 | — | — | US | disclosed |
| US-20170044169-A1 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2017-02-16 | — | — | US | disclosed |
| US-9499549-B2 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2016-11-22 | — | — | US | disclosed |
| US-9499549-B2 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN SCIENCES IRELAND UC (IE) | 2016-11-22 | — | — | US | disclosed |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN R&D IRELAND (IE) | 2015-08-27 | — | — | US | disclosed |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | JANSSEN R&D IRELAND (IE) | 2015-08-27 | — | — | US | disclosed |
| WO-2014056953-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | JANSSEN R&D IRELAND (IE) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11220504-B2 | Pyrrolo[3,2-d] pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | GRIN2B 3233/4885CASR 4175/4885KMT2A 2677/4885 |
| US-20150239892-A1 | Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | GRIN2B 3025/4885CASR 4131/4885KMT2A 2719/4885 |
| US-20170044169-A1 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | GRIN2B 3233/4885CASR 4175/4885KMT2A 2677/4885 |
| US-10259814-B2 | Pyrrolo[3,2-d]pyrimidine derivatives for the treatment of viral infections and other diseases | TYMS, TYMP, DPYD | GRIN2B 3233/4885CASR 4175/4885KMT2A 2677/4885 |
| US-20190330217-A1 | PYRROLO[3,2-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF VIRAL INFECTIONS AND OTHER DISEASES | TYMS, TYMP, DPYD | GRIN2B 3233/4885CASR 4175/4885KMT2A 2677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.