Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.36 |
| ▸ | NAT1 | P18440 | 3/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.30 |
| ▸ | FABP4 | P15090 | 1/20 | 0.30 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6844906 | 0.87 | METAP2 (0.40) | METAP2NAT1ALOX5APFABP4FABP5 | |
| Hydrochloric Acid SCHEMBL1648036 | 0.86 | METAP2 (0.39) | METAP2NAT1ALOX5APFABP4FABP5 | |
| SCHEMBL1649263 | 0.85 | METAP2 (0.37) | METAP2NAT1MMP13 | |
| SCHEMBL18801133 | 0.84 | METAP2 (0.36) | METAP2NAT1FABP4FABP5MMP13 | |
| SCHEMBL14719715 | 0.83 | METAP2 (0.36) | METAP2NAT1FABP4FABP5MMP13 | |
| SCHEMBL1648269 | 0.82 | METAP2 (0.43) | METAP2NAT1FABP4FABP5 | |
| SCHEMBL6844868 | 0.82 | METAP2 (0.35) | METAP2NAT1ALOX5APFABP4FABP5 | |
| SCHEMBL1648904 | 0.82 | PDK2 (0.38) | METAP2NAT1FABP4FABP5MMP13 | |
| SCHEMBL1648412 | 0.82 | CA1 (0.40) | METAP2FABP4FABP5 | |
| SCHEMBL1649052 | 0.82 | CA1 (0.41) | METAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2486004-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | Zafgen Corporation (US) | 2012-08-15 | — | — | EP | disclosed |
| CN-102639494-A | Sulphone compounds and methods of making and using same | ZAFGEN CORP | 2012-08-15 | — | — | CN | disclosed |
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |