Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 4/20 | 0.35 |
| ▸ | NAT1 | P18440 | 3/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GRM6 | O15303 | 1/20 | 0.32 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | FABP4 | P15090 | 1/20 | 0.31 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648322 | 0.91 | METAP2 (0.34) | METAP2NAT1ELANEGRM6MCL1 | |
| SCHEMBL1648908 | 0.89 | METAP2 (0.34) | METAP2NAT1ELANEMCL1 | |
| SCHEMBL1648460 | 0.86 | NAT1 (0.36) | METAP2NAT1ELANEGRM6KDM4E | |
| SCHEMBL1648181 | 0.82 | CA1 (0.40) | METAP2ALDH1A1GLAMAPTHPGD | |
| SCHEMBL1648491 | 0.82 | METAP2 (0.36) | METAP2NAT1ALOX5APFABP4FABP5 | |
| SCHEMBL1648296 | 0.81 | PDK2 (0.37) | METAP2NAT1ELANEMCL1FABP4 | |
| SCHEMBL1648313 | 0.81 | PPARG (0.39) | METAP2KDM4EMEN1ALDH1A1GAA | |
| SCHEMBL1648453 | 0.81 | NPSR1 (0.36) | METAP2NAT1MEN1ALDH1A1GAA | |
| SCHEMBL1648578 | 0.81 | METAP2 (0.43) | METAP2NAT1ELANEGRM6FABP4 | |
| SCHEMBL1648204 | 0.80 | CA12 (0.37) | METAP2MCL1KDM4EALDH1A1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011044506-A2 | SULPHONE COMPOUNDS AND METHODS OF MAKING AND USING SAME | ZAFGEN CORPORATION (US) | 2011-04-14 | — | — | WO | disclosed |