Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.45 |
| ▸ | PGK1 | P00558 | 6/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 5/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16485337 | 0.84 | NLRP3 (0.36) | TLR7TLR8PGK1NLRP3MAP4K2 | |
| SCHEMBL16485121 | 0.81 | CDK1 (0.44) | TLR7TLR8NLRP3CCNA2CDK2 | |
| SCHEMBL11175353 | 0.80 | KDM4E (0.44) | TLR7TLR8PGK1NLRP3CCNA2 | |
| SCHEMBL16482199 | 0.80 | NLRP3 (0.34) | TLR7TLR8PGK1NLRP3 | |
| SCHEMBL13952887 | 0.79 | CCNA2 (0.40) | TLR7TLR8PGK1CCNA2CDK2 | |
| SCHEMBL16485123 | 0.78 | CDK1 (0.44) | TLR7TLR8NLRP3CCNA2CDK2 | |
| SCHEMBL16464736 | 0.78 | NLRP3 (0.33) | TLR7TLR8NLRP3 | |
| SCHEMBL16464464 | 0.78 | TLR8 (0.36) | TLR7TLR8PGK1NLRP3CCNA2 | |
| SCHEMBL16481998 | 0.78 | TLR7 (0.48) | TLR7TLR8PGK1NLRP3CCNA2 | |
| SCHEMBL16482355 | 0.77 | TLR8 (0.38) | TLR7TLR8NLRP3CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9364407-B2 | Hair dye agent comprising aminopyrimidine derivatives | HENKEL AG & CO. KGAA (DE) | 2016-06-14 | — | — | US | disclosed |
| US-9364407-B2 | Hair dye agent comprising aminopyrimidine derivatives | HENKEL AG & CO. KGAA (DE) | 2016-06-14 | — | — | US | disclosed |
| US-20150209257-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2015-07-30 | — | — | US | disclosed |
| US-20150209257-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2015-07-30 | — | — | US | disclosed |
| WO-2014056758-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | HENKEL AG & CO. KGAA (DE) | 2014-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150209257-A1 | HAIR DYE AGENT COMPRISING AMINOPYRIMIDINE DERIVATIVES | H1-4, H1-2, QDPR | TLR7 1875/4885TLR8 990/4885PGK1 3882/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.