Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.74 |
| ▸ | RAB9A | P51151 | 8/20 | 0.74 |
| ▸ | MEN1 | O00255 | 8/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | THRB | P10828 | 2/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17731968 | 0.84 | THRB (0.80) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL17318639 | 0.80 | HSD17B10 (1.00) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6833999 | 0.79 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL4286601 | 0.79 | RAB9A (0.67) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6833804 | 0.76 | NPC1 (0.57) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL21361937 | 0.75 | HPGD (0.70) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6830546 | 0.74 | KMT2A (0.53) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL17732031 | 0.74 | SMN1; SMN2 (0.76) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL6833933 | 0.73 | NPC1 (0.54) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL3413937 | 0.73 | NPC1 (0.63) | NPC1RAB9AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015021943-A9 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-12-30 | — | — | WO | disclosed |
| WO-2015021943-A1 | INDUCING NEUROGENESIS BY AXIN ENHANCER | THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2015-02-19 | — | — | WO | disclosed |