Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 5/20 | 0.50 |
| ▸ | KCNQ2 | O43526 | 5/20 | 0.50 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.36 |
| ▸ | TYMP | P19971 | 1/20 | 0.35 |
| ▸ | ARF6 | P62330 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALPL | P05186 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10062355 | 0.93 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ1TYMPARF6 | |
| SCHEMBL1613890 | 0.87 | KCNQ3 (0.49) | KCNQ3KCNQ2KCNQ1TYMPLDHA | |
| SCHEMBL1613887 | 0.84 | KCNQ3 (0.47) | KCNQ3KCNQ2KCNQ1TYMPARF6 | |
| SCHEMBL1648643 | 0.81 | KCNQ3 (0.41) | KCNQ3KCNQ2KCNQ1TYMPADORA3 | |
| SCHEMBL1279220 | 0.81 | KCNQ3 (0.43) | KCNQ3KCNQ2TYMPARF6LDHA | |
| SCHEMBL1279244 | 0.81 | KCNQ3 (0.42) | KCNQ3KCNQ2TYMPARF6KDM4E | |
| SCHEMBL10062354 | 0.79 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ1ARF6KDM4E | |
| SCHEMBL1278970 | 0.76 | ARF6 (0.52) | KCNQ3KCNQ2TYMPARF6ADORA3 | |
| SCHEMBL1279423 | 0.75 | KCNQ3 (0.43) | KCNQ3KCNQ2ARF6LDHAKDM4E | |
| SCHEMBL1614874 | 0.75 | KCNQ3 (0.38) | KCNQ3KCNQ2LDHAHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | PEKING UNIVERSITY (CN) | 2012-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120088775-A1 | Pyrazolo-[1,5-a]-Pyrimidones Derivatives and Pharmaceutical Compositions and Uses Thereof | KCNJ2, KCNQ5, KCNJ11 | KCNQ3 12/4885KCNQ2 9/4885KCNQ1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.