Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5532401 | 0.86 | DHODH (0.49) | MEN1KMT2AGAASLC22A12DHODH | |
| SCHEMBL14917460 | 0.81 | MEN1 (0.47) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL5838644 | 0.81 | KDM4E (0.46) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL1533663 | 0.81 | MEN1 (0.48) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL27514880 | 0.80 | MEN1 (0.46) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL25229271 | 0.80 | MEN1 (0.47) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL14857133 | 0.80 | MEN1 (0.47) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL8548096 | 0.78 | ADORA3 (0.58) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| Hydrogen Peroxide SCHEMBL28248198 | 0.77 | NTRK1 (0.48) | MEN1KMT2AGAANTRK1PIM1 | |
| SCHEMBL27890738 | 0.77 | KDM4E (0.46) | MEN1KMT2AGAANTRK1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102933584-A | Pyrrolopyrazinone inhibitors of kinases | ABBVIE INC | 2013-02-13 | — | — | CN | claimed |
| CN-117062607-A | Methyl substituted pyridine and pyridazine compounds, derivatives thereof and methods of use thereof | 拉堤果生物医疗股份有限公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-102933584-A | Pyrrolopyrazinone inhibitors of kinases | ABBVIE INC | 2013-02-13 | — | — | CN | disclosed |