Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 10/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 9/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | F7 | P08709 | 1/20 | 0.35 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30174231 | 0.73 | CYP3A4 (0.50) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL27893425 | 0.72 | CYP3A4 (0.51) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL18426271 | 0.70 | CYP1A2 (0.52) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL30702229 | 0.68 | MKNK1 (0.59) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL30702237 | 0.68 | MKNK1 (0.59) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL16487154 | 0.66 | MKNK1 (0.44) | CYP3A4CYP2C19MKNK1MKNK2KCNH2 | |
| SCHEMBL6237449 | 0.65 | MKNK1 (0.62) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL28278998 | 0.64 | CYP1A2 (0.49) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL18426276 | 0.64 | CYP1A2 (0.52) | CYP3A4LMNACYP1A2CYP2C19MKNK1 | |
| SCHEMBL20266951 | 0.64 | MKNK1 (0.51) | MKNK1MKNK2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015022546-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2015-02-19 | — | — | WO | disclosed |