Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | LATS1 | O95835 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.32 |
| ▸ | ATR | Q13535 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.31 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487150 | 0.82 | MKNK1 (0.36) | MKNK1MKNK2TACR1SLC22A2SLC22A1 | |
| SCHEMBL27473965 | 0.73 | MKNK1 (0.46) | MKNK1MKNK2NTRK1PIM1GPBAR1 | |
| SCHEMBL5838649 | 0.71 | MKNK2 (0.44) | MKNK1MKNK2NTRK1PIM1BLM | |
| SCHEMBL23199045 | 0.70 | NTRK1 (0.52) | MKNK1MKNK2TACR1NTRK1PIM1 | |
| SCHEMBL27893425 | 0.70 | CYP3A4 (0.51) | MKNK1MKNK2NTRK1PIM1CYP2C19 | |
| SCHEMBL16487053 | 0.69 | FYN (0.47) | MKNK1MKNK2CYP3A4NPC1MAPT | |
| Acetic Acid SCHEMBL27846617 | 0.68 | NTRK1 (0.50) | MKNK1MKNK2TACR1NTRK1PIM1 | |
| SCHEMBL4307227 | 0.68 | KMO (0.47) | MKNK1MKNK2TACR1GPBAR1CYP2C19 | |
| SCHEMBL14818774 | 0.67 | NOS3 (0.42) | LATS1GRIA2KCNH2NPC1RAB9A | |
| SCHEMBL31119750 | 0.67 | CCNC (0.53) | MKNK1MKNK2NTRK1PIM1PDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3033336-A1 | INHIBITORS OF PLASMA KALLIKREIN | Kalvista Pharmaceuticals Limited (GB) | 2016-06-22 | — | — | EP | disclosed |
| WO-2015022546-A1 | INHIBITORS OF PLASMA KALLIKREIN | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2015-02-19 | — | — | WO | disclosed |