SCHEMBL1648734

SCHEMBL1648734

CCCCCCCCCCCCc1c(C(C)(C)C)cc(O)c(C)c1C(C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 6/20 0.41
TYR P14679 2/20 0.41
CYP19A1 P11511 1/20 0.39
PTGS2 P35354 3/20 0.39
HTT P42858 2/20 0.39
NPC1 O15118 1/20 0.39
HPGD P15428 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
NPSR1 Q6W5P4 1/20 0.39
ALOX15 P16050 3/20 0.38
MAPT P10636 2/20 0.38
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
ATP2A2 P16615 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
ATP2A3 Q93084 1/20 0.38
TP53 P04637 2/20 0.38
CYP3A4 P08684 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1647325 1.00 ALOX5 (0.41) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL688310 0.83 ALOX5 (0.42) ALOX5TYRPTGS2ALDH1A1CYP1A2
SCHEMBL28049310 0.83 ALOX5 (0.42) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL7706320 0.81 ALOX5 (0.44) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL28426211 0.81 ALOX5 (0.44) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL688489 0.79 TYR (0.45) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL755664 0.79 NPC1 (0.43) ALOX5TYRCYP19A1PTGS2HTT
SCHEMBL28416156 0.78 PTGS2 (0.53) ALOX5TYRPTGS2HTTALOX15
SCHEMBL30597898 0.76 TYR (0.43) ALOX5TYRPTGS2KDM4EALDH1A1
SCHEMBL17965869 0.76 TYR (0.45) ALOX5TYRCYP19A1PTGS2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2307528-B1 USE FOR ENHANCING THE LOW TEMPERATURE PROPERTIES OF A FUEL COMPOSITION INNOSPEC FUEL SPECIALTIES LLC (US) 2019-08-28 EP disclosed
EP-2009082-B1 Synergistic lubricating oil composition containing a mixture of a nitro-substituted diarylamine and a diarylamine CHEVRON ORONITE CO (US) 2017-08-30 EP disclosed
US-9493716-B2 Fuel composition with enhanced low temperature properties INNOSPEC LIMITED (GB) 2016-11-15 US disclosed
CN-102149797-B Fuel composition with improved low temperature properties INNOSPEC FUEL SPECIALTIES LLC (US) 2015-08-26 CN disclosed
US-20130025189-A1 FUEL COMPOSITION WITH ENHANCED LOW TEMPERATURE PROPERTIES Innospec Fuel Specialties, LLC (US) 2013-01-31 US disclosed
CN-102149797-A Fuel composition with improved low temperature properties INNOSPEC FUEL SPECIALTIES LLC 2011-08-10 CN disclosed
EP-2307528-A2 FUEL COMPOSITION WITH ENHANCED LOW TEMPERATURE PROPERTIES Innospec Fuel Specialties LLC (US) 2011-04-13 EP disclosed
US-7683017-B2 Synergistic lubricating oil composition containing a mixture of a nitro-substituted diarylamine and a diarylamine CHEVRON ORONITE COMPANY LLC (US) 2010-03-23 US disclosed
US-20100005706-A1 FUEL COMPOSITION WITH ENHANCED LOW TEMPERATURE PROPERTIES Innospec Fuel Specialties, LLC (US) 2010-01-14 US disclosed
WO-2010005947-A2 FUEL COMPOSITION WITH ENHANCED LOW TEMPERATURE PROPERTIES Innospec Fuel Specialties, LLC (US) 2010-01-14 WO disclosed
US-20030000866-A1 Mineral gear oils and transmission fluids LUBRIZOL CORPORATION, THE 2003-01-02 US disclosed
EP-1200540-A1 MINERAL GEAR OILS AND TRANSMISSION FLUIDS THE LUBRIZOL CORPORATION (US) 2002-05-02 EP disclosed
WO-2002016533-A2 EXTENDED DRAIN MANUAL TRANSMISSION LUBRICANTS AND CONCENTRATES THE LUBRIZOL CORPORATION (US) 2002-02-28 WO disclosed
WO-2000071646-A1 MINERAL GEAR OILS AND TRANSMISSION FLUIDS THE LUBRIZOL CORPORATION (US) 2000-11-30 WO disclosed
EP-0712834-B1 High oleic polyol esters, compositions and lubricants functional fluids and greases containing the same LUBRIZOL CORP (US) 1999-07-14 EP disclosed
US-5883057-A MINERAL OILS AND ADDITIVES FOR LUBRICATION THE LUBRIZOL CORPORATION (US) 1999-03-16 US disclosed
EP-0790294-A2 Lubricating compositions The Lubrizol Corporation (US) 1997-08-20 EP disclosed
EP-0786511-A2 Lubricating compositions The Lubrizol Corporation (US) 1997-07-30 EP disclosed
EP-0712834-A1 High oleic polyol esters, compositions and lubricants functional fluids and greases containing the same THE LUBRIZOL CORPORATION (US) 1996-05-22 EP disclosed
EP-0678569-A2 Lubricating compositions with improved oxidation resistance containing a dispersant and an antioxidant THE LUBRIZOL CORPORATION (US) 1995-10-25 EP disclosed