Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.65 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | OGT | O15294 | 5/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.56 |
| ▸ | ITGAV | P06756 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16487594 | 0.90 | OGT (0.75) | CYP3A4CYP2D6CYP2C9MAPTALDH1A1 | |
| SCHEMBL16487676 | 0.89 | MEN1 (0.77) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487652 | 0.86 | MEN1 (0.70) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487685 | 0.86 | OGT (0.80) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487611 | 0.84 | MAPT (0.74) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487683 | 0.84 | THRB (0.75) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487668 | 0.84 | MEN1 (0.69) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487672 | 0.84 | OGT (0.75) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487628 | 0.84 | MEN1 (0.69) | CYP3A4CYP2D6MEN1KMT2AMAPT | |
| SCHEMBL16487633 | 0.83 | MAPT (0.73) | CYP3A4CYP2D6MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8957075-B2 | O-GlcNAc transferase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-02-17 | — | — | US | disclosed |
| US-8957075-B2 | O-GlcNAc transferase inhibitors and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2015-02-17 | — | — | US | disclosed |