Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | MGLL | Q99685 | 1/20 | 0.42 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | MC4R | P32245 | 2/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.36 |
| ▸ | RORC | P51449 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3659452 | 0.96 | APP (0.54) | APPMGLLPTGER1CNR1PSEN1 | |
| SCHEMBL3659869 | 0.88 | APP (0.62) | APPPTGER1CNR1PSEN1PSEN2 | |
| SCHEMBL10301252 | 0.82 | APP (0.51) | APPCNR1PSEN1PSEN2APH1B | |
| SCHEMBL3714638 | 0.79 | APP (0.55) | APPDHODHPTGDR2 | |
| SCHEMBL8031372 | 0.78 | APP (0.49) | APPDHODHPTGDR2AKR1C3AKR1C2 | |
| SCHEMBL1201218 | 0.77 | APP (0.72) | APPCNR1PSEN1PSEN2APH1B | |
| SCHEMBL8044676 | 0.77 | APP (0.59) | APPPTGER1CNR1PSEN1PSEN2 | |
| SCHEMBL15494189 | 0.77 | APP (0.47) | APPDHODHPTGDR2 | |
| SCHEMBL3961703 | 0.77 | APP (0.41) | APPDHODHPTGDR2RORC | |
| SCHEMBL3659554 | 0.76 | CNR2 (0.39) | APPCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234954-B1 | TETRASUBSTITUTED BENZENES | ENVIVO PHARMACEUTICALS INC (US) | 2015-02-18 | — | — | EP | disclosed |