Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATP4A | P20648 | 3/20 | 0.40 |
| ▸ | ATP4B | P51164 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 13/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 13/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1343450 | 0.93 | HSP90AA1 (0.44) | ATP4AATP4BHSP90AA1HSP90AB1G6PD | |
| SCHEMBL1149751 | 0.76 | HSP90AA1 (0.34) | ATP4AATP4BHSP90AA1HSP90AB1 | |
| SCHEMBL1148712 | 0.76 | HSP90AA1 (0.43) | HSP90AA1HSP90AB1 | |
| SCHEMBL14525261 | 0.73 | HSP90AA1 (0.39) | HSP90AA1HSP90AB1 | |
| SCHEMBL1147557 | 0.70 | HSP90AA1 (0.41) | HSP90AA1HSP90AB1 | |
| SCHEMBL1149684 | 0.69 | KDM4E (0.35) | HSP90AA1HSP90AB1 | |
| SCHEMBL14618520 | 0.68 | ATP4A (0.35) | ATP4AATP4B | |
| SCHEMBL931155 | 0.68 | GAA (0.41) | ATP4AATP4BHSP90AA1HSP90AB1 | |
| SCHEMBL1147829 | 0.67 | HSP90AA1 (0.49) | HSP90AA1HSP90AB1 | |
| SCHEMBL3106385 | 0.66 | HSP90AA1 (0.46) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951679-B1 | IMIDAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP (US) | 2015-02-18 | — | — | EP | disclosed |