SCHEMBL16489004

SCHEMBL16489004

O=C(O)c1ccccc1Nc1cc(Cl)c([N+](=O)[O-])cc1Cl

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC25A1 P53007 1/20 0.59
▸ MEN1 O00255 4/20 0.59
▸ KMT2A Q03164 4/20 0.59
▸ AKR1C3 P42330 5/20 0.57
▸ AKR1C2 P52895 4/20 0.57
▸ AKR1B1 P15121 2/20 0.57
▸ AKR1C4 P17516 2/20 0.57
▸ AKR1C1 Q04828 2/20 0.57
▸ AKR1B10 O60218 1/20 0.57
▸ MYC P01106 1/20 0.54
▸ FABP3 P05413 2/20 0.53
▸ FABP4 P15090 2/20 0.53
▸ FABP5 Q01469 2/20 0.53
▸ PBRM1 Q86U86 1/20 0.52
▸ TTR P02766 2/20 0.51
▸ MAPT P10636 2/20 0.51
▸ KDM4E B2RXH2 2/20 0.51
▸ USP2 O75604 1/20 0.51
▸ MT-CO2 P00403 1/20 0.51
▸ LMNA P02545 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16489006 0.83 SLC25A1 (0.65) SLC25A1MEN1KMT2AAKR1C3AKR1C2
SCHEMBL29532900 0.81 AKR1C3 (0.67) SLC25A1MEN1KMT2AAKR1C3AKR1C2
SCHEMBL16489005 0.81 AKR1C3 (0.67) SLC25A1MEN1KMT2AAKR1C3AKR1C2
SCHEMBL2112961 0.81 AKR1C3 (0.67) SLC25A1MEN1KMT2AAKR1C3AKR1C2
SCHEMBL16489011 0.81 MYC (0.60) SLC25A1MEN1KMT2AAKR1C3AKR1C2
SCHEMBL453183 0.81 AKR1C3 (0.68) MEN1KMT2AAKR1C3AKR1C2AKR1B1
SCHEMBL6141546 0.79 PBRM1 (0.68) MEN1KMT2AAKR1C3AKR1C2AKR1B1
SCHEMBL23567 0.78 AKR1C3 (0.67) MEN1KMT2AAKR1C3AKR1C2AKR1B1
SCHEMBL29785279 0.78 AKR1C3 (0.67) MEN1KMT2AAKR1C3AKR1C2AKR1B1
SCHEMBL29377063 0.78 AKR1C3 (0.67) MEN1KMT2AAKR1C3AKR1C2AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION CHOUDHARY MUHAMMAD IQBAL (PK) 2015-02-19 — — US disclosed
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION CHOUDHARY MUHAMMAD IQBAL (PK) 2015-02-19 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051286-A1 ANTHRANILIC ACID DERIVATIVES: NOVEL INHIBITORS OF ADVANCED GLYCATION END-PRODUCTS (AGES) FORMATION AGER, NFKBIA, DNPEP SLC25A1 2255/4885MEN1 3683/4885KMT2A 2971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback