Sugi Predict

Sugi Predict / Targets / SLC25A1

SLC25A1

Tricarboxylate transport protein, mitochondrial · P53007 · SLC25A1 on Sugi Atlas →

715 patent compounds predicted against SLC25A1, 612 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL24215474 SCHEMBL24215474 0.63 2/20
SCHEMBL30515749 SCHEMBL30515749 0.63 2/20
SCHEMBL7371667 SCHEMBL7371667 0.58 2/20
SCHEMBL5059972 SCHEMBL5059972 0.56 2/20
SCHEMBL6204952 SCHEMBL6204952 0.53 2/20
SCHEMBL6205157 SCHEMBL6205157 0.53 2/20
SCHEMBL6205161 SCHEMBL6205161 0.53 2/20
SCHEMBL10715096 SCHEMBL10715096 0.50 2/20
SCHEMBL11780362 SCHEMBL11780362 0.47 2/20
SCHEMBL6564234 SCHEMBL6564234 0.43 2/20
SCHEMBL5598171 SCHEMBL5598171 1.00 1/20
SCHEMBL17329296 SCHEMBL17329296 1.00 1/20
SCHEMBL29918322 SCHEMBL29918322 1.00 1/20
SCHEMBL30000258 SCHEMBL30000258 1.00 1/20
SCHEMBL30252330 SCHEMBL30252330 1.00 1/20
SCHEMBL30777865 SCHEMBL30777865 1.00 1/20
SCHEMBL10389335 SCHEMBL10389335 0.75 1/20
SCHEMBL27770307 SCHEMBL27770307 0.73 1/20
SCHEMBL31404880 SCHEMBL31404880 0.72 1/20
SCHEMBL13146602 SCHEMBL13146602 0.69 1/20

Clinical trials — most relevant to SLC25A1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve) PHASE3WITHDRAWN
Acetylcarnitine and Insulin Sensitivity PHASE2COMPLETED
Atorvastatin, L-Carnitine and Non-Alcoholic Steatohepatitis PHASE2UNKNOWN
Metabolic Cofactor Supplementation in Alzheimer's Disease (AD) and Parkinson's Disease (PD) Patients PHASE2COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder PHASE2WITHDRAWN
The Effects of Coenzyme A Combined With Abiraterone on Patients With CRPC PHASE1/PHASE2UNKNOWN
A Study of Bezafibrate in Mitochondrial Myopathy PHASE2COMPLETED
Effects of Coenzyme Q10 on Charcot-Marie-Tooth Disease PHASE1/PHASE2COMPLETED
Carnitine Consumption and Augmentation in Pulmonary Arterial Hypertension PHASE1COMPLETED
A Pilot Study to Examine the Effects of Vitamin D Supplementation on Mitochondrial Bioenergetics in Older Adults EARLY_PHASE1COMPLETED
Expression of SLC25A48 in Chronic Obstructive Pulmonary Disease nanNOT_YET_RECRUITING
Multi-omics Study in Citrin Deficiency nanACTIVE_NOT_RECRUITING
Natural History Study of SLC25A46 Mutation-related Mitochondriopathy nanCOMPLETED
Genetic Variations That Increase the Risk for Calcium Kidney Stones: a Family-based Study nanCOMPLETED
SLC13A5 Deficiency Natural History Study - United States Only nanENROLLING_BY_INVITATION
Triheptanoin (UX007) to Treat Citrate Transporter Deficiency nanNO_LONGER_AVAILABLE
Tissue Sample Study for Mitochondrial Disorders nanENROLLING_BY_INVITATION
Mitoquines in COPD nanUNKNOWN
Survey on Supplement Use in Mitochondrial Disease nanCOMPLETED
GDF-15 as a Biomarker for Mitochondrial Disease nanCOMPLETED
Mitochondrial Assessment in Critical Ill Patients in Intensive Care nanNOT_YET_RECRUITING
The RolE oF Androgen Excess in MUscle Energy MetaboLism in Women With PolyCystic Ovary Syndrome (REFUEL PCOS) Study 2 nanUNKNOWN
TBI Multimodal Monitoring Study nanUNKNOWN
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes nanNOT_YET_RECRUITING
The Natural History of Mitochondrial Diseases nanRECRUITING
Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids nanCOMPLETED
Exercise Training Effects on Muscle Function in Adults With Mitochondrial Myopathy nanRECRUITING
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer) nanCOMPLETED
Calf Muscle Strength in Mitochondrial Diseases nanCOMPLETED
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC) nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a SLC25A1 binder may also engage these)

ProteinNameSimilarity
P32089 — 1.000 P32089 →
P79110 — 1.000 P79110 →
Q8JZU2 — 1.000 Q8JZU2 →
F1R4U0 — 0.978 F1R4U0 →
P97700 — 0.966 P97700 →
SLC25A11 Mitochondrial 2-oxoglutarate/malate carrier protein 0.963 landscape →
P22292 — 0.963 P22292 →
Q9CR62 — 0.960 Q9CR62 →
Q9CR58 — 0.955 Q9CR58 →
Q5PQM9 — 0.950 Q5PQM9 →
P51881 — 0.949 P51881 →
Q8SQH5 — 0.946 Q8SQH5 →
F1RFX9 — 0.945 F1RFX9 →
SLC25A5 ADP/ATP translocase 2 0.945 landscape →
Q05962 — 0.944 Q05962 →
SLC25A6 ADP/ATP translocase 3 0.944 landscape →
Q5R5A1 — 0.944 Q5R5A1 →
Q8HXE3 — 0.943 Q8HXE3 →
Q09073 — 0.941 Q09073 →
P48962 — 0.941 P48962 →
P32007 — 0.941 P32007 →
SLC25A4 ADP/ATP translocase 1 0.941 landscape →
Q6GQ22 — 0.940 Q6GQ22 →
P02722 — 0.940 P02722 →
Q5SVS4 — 0.936 Q5SVS4 →
Q6QRN9 — 0.935 Q6QRN9 →
Q000K2 — 0.934 Q000K2 →
O95258 — 0.932 O95258 →
Q5XGI1 — 0.932 Q5XGI1 →
O89035 — 0.931 O89035 →