Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 2/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | RARA | P10276 | 1/20 | 0.33 |
| ▸ | RARG | P13631 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16080631 | 0.84 | KLKB1 (0.38) | GAAPLAUKLKB1KDM1A | |
| SCHEMBL15633641 | 0.84 | KLKB1 (0.38) | GAAPLAUKLKB1KDM1A | |
| SCHEMBL15633640 | 0.84 | KLKB1 (0.38) | GAAPLAUKLKB1KDM1A | |
| SCHEMBL13631338 | 0.80 | IDO1 (0.44) | MAP2K2MAP2K1PLAUTRPA1KLKB1 | |
| SCHEMBL27894275 | 0.79 | TRPA1 (0.37) | MAP2K2MAP2K1TRPA1RARBRARA | |
| SCHEMBL10211142 | 0.79 | DGAT1 (0.55) | MAP2K2MAP2K1TRPA1RARBRARA | |
| SCHEMBL29361102 | 0.77 | GAA (0.42) | GAAMAP2K2MAP2K1SMN1; SMN2KMT2A | |
| SCHEMBL17730394 | 0.77 | GAA (0.42) | GAAMAP2K2MAP2K1SMN1; SMN2KMT2A | |
| SCHEMBL17737798 | 0.77 | GAA (0.42) | GAAMAP2K2MAP2K1SMN1; SMN2KMT2A | |
| SCHEMBL17730395 | 0.77 | GAA (0.42) | GAAMAP2K2MAP2K1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9266828-B2 | Inhibitors of Furin and other pro-protein convertases | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2016-02-23 | — | — | US | disclosed |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE | 2015-03-12 | — | — | US | disclosed |
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE (US) | 2015-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150051138-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | GAA 1644/4885MAP2K2 2378/4885MAP2K1 2444/4885 |
| US-20150073054-A1 | INHIBITORS OF FURIN AND OTHER PRO-PROTEIN CONVERTASES | FURIN, PREP, PCSK6 | GAA 1644/4885MAP2K2 2378/4885MAP2K1 2444/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.