SCHEMBL16490207

SCHEMBL16490207

c1ccc2c(c1)-c1ccccc1N(c1ccc3c(c1)-c1cc(N4c5ccccc5-c5ccccc5-c5ccccc54)cc4cccc-3c14)c1ccccc1-2

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
TSHR P16473 3/20 0.43
MAPK1 P28482 3/20 0.43
HSD17B10 Q99714 3/20 0.43
CASP1 P29466 3/20 0.43
HPGD P15428 3/20 0.43
HIF1A Q16665 2/20 0.43
TP53 P04637 2/20 0.43
CASP7 P55210 2/20 0.43
L3MBTL1 Q9Y468 2/20 0.42
ATM Q13315 1/20 0.42
KLK7 P49862 1/20 0.37
PSMD14 O00487 1/20 0.37
POLB P06746 1/20 0.37
MMP2 P08253 1/20 0.37
PDE6D O43924 1/20 0.36
CYP3A4 P08684 1/20 0.36
PABPC1 P11940 1/20 0.36
DNMT1 P26358 1/20 0.36
MEN1 O00255 4/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16490214 1.00 ALDH1A1 (0.43) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490213 0.94 ALDH1A1 (0.48) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490206 0.92 ALDH1A1 (0.52) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL24254003 0.82 ALDH1A1 (0.52) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490203 0.79 ALDH1A1 (0.37) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490186 0.78 KEAP1 (0.40) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490194 0.78 KEAP1 (0.40) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL21735662 0.77 ALDH1A1 (0.36) ALDH1A1TSHRMAPK1HSD17B10CASP1
SCHEMBL16490190 0.77 PDE6D (0.38) ALDH1A1TSHRMAPK1HSD17B10HPGD
SCHEMBL16490191 0.77 PDE6D (0.38) ALDH1A1TSHRMAPK1HSD17B10HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9882139-B2 Heterocyclic compound and organic light-emitting diode including the same SAMSUNG DISPLAY CO., LTD. (KR) 2018-01-30 US disclosed
US-9882139-B2 Heterocyclic compound and organic light-emitting diode including the same SAMSUNG DISPLAY CO., LTD. (KR) 2018-01-30 US disclosed
US-20150048324-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2015-02-19 US disclosed
US-20150048324-A1 HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DIODE INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2015-02-19 US disclosed