Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Aminoquinuride. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNG2 | P59768 | 3/20 | 0.94 |
| ▸ | GNB1 | P62873 | 3/20 | 0.94 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.94 |
| ▸ | MEN1 | O00255 | 1/20 | 0.94 |
| ▸ | MMP1 | P03956 | 1/20 | 0.94 |
| ▸ | MMP9 | P14780 | 1/20 | 0.94 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.94 |
| ▸ | BLM | P54132 | 1/20 | 0.94 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.61 |
| ▸ | APAF1 | O14727 | 1/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | UBE2N | P61088 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminoquinuride SCHEMBL321401 | 0.97 | GNG2 (1.00) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL29852258 | 0.97 | GNG2 (1.00) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL14690654 | 0.96 | GNG2 (0.97) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL17699230 | 0.96 | GNG2 (0.97) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL6765142 | 0.96 | GNG2 (0.97) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL14690740 | 0.94 | GNG2 (0.94) | GNG2GNB1KMT2AMEN1MMP1 | |
| Aminoquinuride SCHEMBL14690424 | 0.93 | GNG2 (0.92) | GNG2GNB1KMT2AMEN1MMP1 | |
| SCHEMBL8359605 | 0.88 | GNG2 (0.83) | GNG2GNB1KMT2AMEN1MMP1 | |
| SCHEMBL14703871 | 0.87 | GNG2 (0.81) | GNG2GNB1KMT2AMEN1MMP1 | |
| SCHEMBL7763069 | 0.87 | GNG2 (0.81) | GNG2GNB1KMT2AMEN1MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104105500-B | Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions | 伊西康公司 | 2020-05-19 | — | — | CN | disclosed |
| EP-2760462-B1 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS | ETHICON INC (US) | 2019-07-31 | — | — | EP | disclosed |
| US-9220814-B2 | Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions | ETHICON, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-9205179-B2 | Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions | ETHICON, INC. (US) | 2015-12-08 | — | — | US | disclosed |
| CN-104105500-A | Broad-spectrum antimicrobial compositions based on combinations of taurolidine and protamine and medical devices containing such compositions | ETHICON INC | 2014-10-15 | — | — | CN | disclosed |
| EP-2760462-A2 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS | Ethicon, Inc (US) | 2014-08-06 | — | — | EP | disclosed |
| US-20130251774-A1 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS | ETHICON, INC. (US) | 2013-09-26 | — | — | US | disclosed |
| WO-2013049149-A2 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS | ETHICON, INC. (US) | 2013-04-04 | — | — | WO | disclosed |
| US-20130084319-A1 | BROAD-SPECTRUM ANTIMICROBIAL COMPOSITIONS BASED ON COMBINATIONS OF TAUROLIDINE AND PROTAMINE AND MEDICAL DEVICES CONTAINING SUCH COMPOSITIONS | ETHICON, INC. | 2013-04-04 | — | — | US | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |