Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 2/20 | 0.76 |
| ▸ | SERPINA6 | P08185 | 4/20 | 0.56 |
| ▸ | SHBG | P04278 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.55 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.55 |
| ▸ | BLM | P54132 | 2/20 | 0.55 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.55 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | PGR | P06401 | 3/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | TSHR | P16473 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Algestone Acetophenide SCHEMBL282250 | 1.00 | CYP17A1 (0.76) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| Algestone Acetophenide SCHEMBL3039564 | 1.00 | CYP17A1 (0.76) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| Algestone Acetonide SCHEMBL42582 | 0.87 | CYP17A1 (0.85) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL29500568 | 0.87 | CYP17A1 (1.00) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL29409283 | 0.87 | CYP17A1 (1.00) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL4541005 | 0.87 | CYP17A1 (1.00) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL7993136 | 0.87 | CYP17A1 (1.00) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL4539514 | 0.87 | CYP17A1 (1.00) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL151266 | 0.77 | CYP17A1 (0.76) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 | |
| SCHEMBL19505758 | 0.76 | SHBG (0.53) | CYP17A1SERPINA6SHBGLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114085261-A | Preparation method of megestrol and intermediate thereof | 浙江仙琚制药股份有限公司 | 2022-02-25 | — | — | CN | disclosed |
| US-7927613-B2 | Pharmaceutical co-crystal compositions | UNIVERSITY OF SOUTH FLORIDA (US) | 2011-04-19 | — | — | US | disclosed |
| US-7790905-B2 | Pharmaceutical propylene glycol solvate compositions | MCNEIL-PPC, INC. (US) | 2010-09-07 | — | — | US | disclosed |