Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 2/20 | 0.41 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16495119 | 0.88 | CYP1A2 (0.39) | JAK2CYP1A2GRIA1KDRPLK4 | |
| SCHEMBL16494828 | 0.87 | JAK2 (0.44) | JAK2EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL16494693 | 0.86 | JAK2 (0.43) | JAK2EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL16494255 | 0.84 | JAK2 (0.43) | JAK2KDRCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL16494404 | 0.84 | JAK2 (0.44) | JAK2EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL16495136 | 0.84 | JAK2 (0.42) | JAK2KDRCYP3A4CYP2C9CYP2D6 | |
| SCHEMBL11915869 | 0.80 | JAK2 (0.45) | JAK2EPHB4KDRCYP3A4CYP2C9 | |
| SCHEMBL16494276 | 0.78 | JAK2 (0.47) | JAK2EPHB4KDRIGF1RPLK4 | |
| SCHEMBL16494732 | 0.75 | JAK2 (0.35) | JAK2KDRCYP3A4CYP2C9MAPK1 | |
| SCHEMBL16495003 | 0.73 | JAK2 (0.36) | JAK2KDRCYP3A4CYP2C9GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |