Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 16/20 | 0.40 |
| ▸ | KIT | P10721 | 7/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 7/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16494693 | 0.87 | JAK2 (0.43) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL16494255 | 0.87 | JAK2 (0.43) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL16494828 | 0.84 | JAK2 (0.44) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL16494274 | 0.84 | JAK2 (0.43) | JAK2KDRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16494404 | 0.83 | JAK2 (0.44) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL11915869 | 0.81 | JAK2 (0.45) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL16495140 | 0.79 | JAK2 (0.47) | JAK2KDR | |
| SCHEMBL16495003 | 0.78 | JAK2 (0.36) | JAK2KDRKITPDGFRACYP3A4 | |
| SCHEMBL16494732 | 0.74 | JAK2 (0.35) | JAK2KDRCYP3A4CYP2D6CYP2C9 | |
| SCHEMBL16495119 | 0.73 | CYP1A2 (0.39) | JAK2KDRPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |