Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 4/20 | 0.38 |
| ▸ | HTR2C | P28335 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14839993 | 0.94 | HTR2A (0.42) | HTR2AHTR1DMTNR1AMTNR1BGAA | |
| SCHEMBL14839743 | 0.89 | HTR2A (0.49) | HTR2AMTNR1AMTNR1BMEN1KMT2A | |
| SCHEMBL16495190 | 0.86 | HTR2A (0.41) | HTR2AHTR1DMTNR1AMTNR1BGAA | |
| SCHEMBL16494885 | 0.86 | HTR2A (0.41) | HTR2AHTR1DMTNR1AMTNR1BGAA | |
| SCHEMBL16494950 | 0.86 | PAK4 (0.45) | HTR2AHTR1DMTNR1AMTNR1BGAA | |
| SCHEMBL16494248 | 0.85 | HTR2A (0.40) | HTR2AHTR1DMTNR1AMTNR1BGAA | |
| SCHEMBL16495045 | 0.85 | HTR1A (0.40) | HTR2AHTR1AHTR2CDRD2HTR7 | |
| SCHEMBL16494650 | 0.84 | HTR1A (0.39) | HTR2AHTR1DHTR1AHTR2CDRD2 | |
| SCHEMBL16494871 | 0.84 | HTR1A (0.42) | HTR2AHTR1DHTR1AHTR2CDRD2 | |
| SCHEMBL14839726 | 0.83 | MPO (0.47) | HTR2AMTNR1AMTNR1BHTR1AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2395001-A1 | Novel pyrimidine derivatives | Chemilia AB (SE) | 2011-12-14 | — | — | EP | disclosed |