Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.47 |
| ▸ | MMP14 | P50281 | 4/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | ADAMTS4 | O75173 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155448 | 0.86 | MMP13 (0.48) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL27693798 | 0.86 | MMP13 (0.45) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL2154777 | 0.84 | MMP13 (0.46) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL27693800 | 0.80 | MMP13 (0.49) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL2154774 | 0.80 | MMP13 (0.64) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL4813052 | 0.77 | MMP13 (0.55) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL27693778 | 0.74 | MMP13 (0.46) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL2154781 | 0.74 | MMP13 (0.44) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL2156163 | 0.74 | MMP13 (0.50) | MMP13MMP14CYP3A4ADAMTS4TP53 | |
| SCHEMBL27713643 | 0.74 | TP53 (0.44) | MMP13MMP14CYP3A4ADAMTS4TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | disclosed |